Autobahn A 5 from Frankfurt:

• Take exit Dossenheim.

• Continue direction Dossenheim / Heidelberg (approx. 2 km).

• In Heidelberg-Handschuhsheim, when the road splits left/right, turn right (signpost Universitätskliniken).

• After leaving Heidelberg-Handschuhsheim, turn right the first street after tram stop "Heiligenbergschule" and just before the main road turns left (first access to Neuenheimer Feld/Technologiepark).

• DKFZ/Im Neuenheimer Feld 580 is located on the left side of the street.

• From Autobahn A 5 (Karlsruhe): At Autobahn junction Heidelberg change to A 656

• At end of Autobahn, take left lane and follow signpost Zoo / Chirurgie / Technologiepark

• You must cross the Neckar river; to do so you must pass under the bridge first. Just stay on the right lane after you have left the Autobahn.

• After the river crossing, continue straight on (approx. 2km), passing all of the Neuenheimer Feld/Technologiepark.

• After the main road turned right, take the first opportunity to turn left (2nd signpost Technologiepark; that is one after the Zoo).

• DKFZ/Im Neuenheimer Feld 580 is located on the left side of the street.

• Take
  Tram No. 21 direction Handschuhsheim (OEG Bf.) or
  Tram No. 24 direction Handschuhsheim 

• Get off at stop Technologiepark

• DKFZ/Im Neuenheimer Feld 580 is located 50m ahead on the left side.

• Take Lufthansa bus shuttle from the airport to Heidelberg Crowne Plaza Hotel, Kurfürstenanlage 1-3 near Adenauerplatz.

• Take Tram No. 21 direction Handschuhsheim (OEG Bf.)

• Get off at stop Technologiepark

• DKFZ/Im Neuenheimer Feld 580 is located 50m ahead on the left side